ADVOS is the world’s first method for the combined multi-organ support of liver, lung, kidney, and acid-base balance. Based on the principle of albumin dialysis, ADVOS allows extracorporeal fluid-based elimination of CO2, hepatic toxins, water-soluble and protein-bound nephrotoxins, as well as the correction of metabolic and respiratory acidosis. The ADVOS method works with typical dialysis accesses and flow rates and does not require any gas exchangers for CO2 elimination.
Despite the progress made in intensive care, the mortality rate of patients with multi-organ support is still very high. Although the dysfunctions of the individual detoxification organs liver, lungs and kidneys can clearly be delineated, failure of one organ can affect several others. Examples are hepato-renal, reno-cardiac, or cardio-pulmonary syndromes, where the severity of the pathology correlates directly with the number of decompensated organs. Due to the reduced function of the main detoxification organs, life-threatening toxins accumulate in the body which leads to subsequent progressive organ failure and death within a few days.
Conventional extracorporeal procedures merely support the function of one or two organs. The innovative approach of ADVOS, on the other hand, deals with multi-organ support with a combined support of all three main detoxification organs.
Scope of Application
ADVOS offers a wide range of therapies for the treatment of patients with insufficiency of one or more detoxification organs and is mainly used in intensive care units for the following indications:
Removal of hepatic toxins
Extracorporeal fluid-based CO2 removal
Removal of water-soluble and additionally protein-bound nephrotoxins
Correction of metabolic and respiratory acidosis without bicarbonate addition
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